Selective enzymatic reduction of aldehydes.
نویسندگان
چکیده
Highly selective enzymatic reductions of aldehydes to the corresponding alcohols was performed using an E. coli JM109 whole cell biocatalyst. A selective enzymatic method for the reduction of aldehydes could provide an eco-compatible alternative to chemical methods. The simplicity, fairly wide scope and the very high observed chemoselectivity of this approach are its most unique features.
منابع مشابه
Asymmetric total synthesis of (-)-callystatin A employing the SAMP/RAMP hydrazone alkylation methodology.
[structure: see text] The asymmetric total synthesis of (-)-callystatin A has been achieved. The key steps generating the stereogenic centers rely on the asymmetric alpha-alkylation of aldehydes or ketones exploiting the SAMP/RAMP hydrazone alkylation methodology, as well as an enzymatic enantioselective reduction of a 3,5-dioxocarboxylate. For the construction of the alkene moieties, highly se...
متن کاملPolymer Supported Zinc Borohydride: A Stable, Efficient, Selective, and Regenerable Reducing Agent for Variety of Organic Compounds
The difficult to handle and store zinc borohydride, Zn(BH4)2, is stabilized by supporting it on polyvinylpyridine. This new mild, efficient, selective, and regenerable polymer supported borohydride reducing agent reduces a variety organic compounds such as, aldehydes, a-b-unsaturated carbonyl compounds, acid chlorides, epoxides, disu...
متن کاملAmperometric determination of alcohols, aldehydes and carboxylic acids with an immobilized alcohol oxidase enzyme electrode.
Chemical tests for measurement of blood alcohols are the subject of much interest. particularly in legal cases, and there is a need for quick, simple and reliable assay methods. Likewise. the determinations of carboxylic acids and aldehydes are of importance in various industrial fields, but such assays are difficult to carry out. especially at low concentrations. In the past. alcohols_ have be...
متن کاملFour distinct types of E.C. 1.2.1.30 enzymes can catalyze the reduction of carboxylic acids to aldehydes.
Increasing demand for chemicals from renewable resources calls for the development of new biotechnological methods for the reduction of oxidized bio-based compounds. Enzymatic carboxylate reduction is highly selective, both in terms of chemo- and product selectivity, but not many carboxylate reductase enzymes (CARs) have been identified on the sequence level to date. Thus far, their phylogeny i...
متن کاملSelective reduction of carboxylic acids to aldehydes through manganese catalysed hydrosilylation.
The direct reduction of carboxylic acids to disilylacetals was achieved through a manganese catalyzed hydrosilylation reaction in the presence of triethylsilane under mild conditions, at r.t. and under UV irradiation (350 nm). The aldehydes were obtained in good to excellent yields after acidic hydrolysis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecules
دوره 11 5 شماره
صفحات -
تاریخ انتشار 2006